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Effects point out which the effects with the benzodiazepine web page ligands zolpidem, zopiclone, Cl218872, L-655,708 and DMCM had been approximately entirely eliminated in all mutated receptors up to a one microM focus. The effects of bretazenil, Ro15-1788 or abecarnil were being removed in certain, but not all mutated receptors, suggesting that the gamma 2F77I mutation differentially more info influences the steps of these ligands in several receptor subtypes. In addition, this point mutation also influences the efficacy of diazepam for boosting GABA-induced chloride flux, suggesting the amino acid residue gamma 2F77 may additionally be associated with the transduction in the effect of benzodiazepines from binding to gating.
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